https://github.com/cython/cython/pull/5210
https://github.com/cython/cython/pull/5211

--- contrib/tools/cython/Cython/Utility/Embed.c	(19fe9379d5dd7e26afd2405b1890080712d1892c)
+++ contrib/tools/cython/Cython/Utility/Embed.c	(bdf71953ac311b76dcfb2ffd7ec4b71a018ed416)
@@ -28,6 +28,7 @@ static int __Pyx_main(int argc, wchar_t **argv) {
     m = fpgetmask();
     fpsetmask(m & ~FP_X_OFL);
 #endif
+#if PY_VERSION_HEX < 0x03080000
     if (argc && argv) {
         Py_InitArgcArgv(argc, argv);
         Py_SetProgramName(argv[0]);
@@ -35,6 +36,38 @@ static int __Pyx_main(int argc, wchar_t **argv) {
     Py_Initialize();
     if (argc && argv)
         PySys_SetArgv(argc, argv);
+#else
+    {
+        PyStatus status;
+
+        PyConfig config;
+        PyConfig_InitPythonConfig(&config);
+        // Disable parsing command line arguments
+        config.parse_argv = 0;
+
+        if (argc && argv) {
+            status = PyConfig_SetString(&config, &config.program_name, argv[0]);
+            if (PyStatus_Exception(status)) {
+                PyConfig_Clear(&config);
+                return 1;
+            }
+
+            status = PyConfig_SetArgv(&config, argc, argv);
+            if (PyStatus_Exception(status)) {
+                PyConfig_Clear(&config);
+                return 1;
+            }
+        }
+
+        status = Py_InitializeFromConfig(&config);
+        if (PyStatus_Exception(status)) {
+            PyConfig_Clear(&config);
+            return 1;
+        }
+
+        PyConfig_Clear(&config);
+    }
+#endif
     { /* init module '%(module_name)s' as '__main__' */
       PyObject* m = NULL;
       %(module_is_main)s = 1;