--- a/setup.py
+++ b/setup.py
@@ -299,11 +299,11 @@
     RE2_INCLUDE = (os.path.join('/usr', 'include', 're2'),)
 
 EXTENSION_INCLUDE_DIRECTORIES = ((PYTHON_STEM,) + CORE_INCLUDE + ABSL_INCLUDE +
-                                 ADDRESS_SORTING_INCLUDE + CARES_INCLUDE +
-                                 RE2_INCLUDE + SSL_INCLUDE + UPB_INCLUDE +
+                                 ADDRESS_SORTING_INCLUDE +
+                                 RE2_INCLUDE + UPB_INCLUDE +
                                  UPB_GRPC_GENERATED_INCLUDE +
                                  UPBDEFS_GRPC_GENERATED_INCLUDE +
-                                 XXHASH_INCLUDE + ZLIB_INCLUDE)
+                                 XXHASH_INCLUDE)
 
 EXTENSION_LIBRARIES = ()